The LCK Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to Lck, and p56lck. This antibody recognizes Human, Mouse, and Rat antigen. The LCK Antibody has been validated for the following applications: Immunohistochemistry, and Western Blot.
Description
The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells (1). Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active (2)